Bioway Consulting SL

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Native Lacotferrin - the key difference

In the pharmaceutical sector, it is critical whether the lactoferrin is in the apo form (low in iron, < 5% saturated) or the holo form (iron-saturated), as this determines its biological activity. Lactoferrin holds iron (Fe³⁺) in a specific binding pocket, which is stabilised by amino acids and a carbonate ion (CO₃⁻).
The distinction between apo-, native- and holo-lactoferrin (Lf) is based primarily on the protein’s degree of iron saturation, which is decisive for its biological function and stability.

Most manufacturers, such as the world’s largest producer, MILEI GmbH, or suppliers like artgerecht (LFERRIN CLN®), focus on high-purity lactoferrin with a low iron content. Reason: The high iron-binding capacity of the apo form is considered the main benefit for the immune system and the regulation of iron balance. Technically, it is difficult to manufacture a 100% iron-free product, which is why mixtures with a very low iron content are sold as standard.The process developed by Bioway overcomes drawbacks, as it is automated and operates in standardised, scalable modules. It is carried out under cooled conditions (4–8°C) and is based on electro-alkalisation, which precipitates the protein at its isoelectric point (IEP), where solubility is at its lowest. It is a ‘ONE-STEP’ process.

Gold Standard

As lactoferrin precipitates within a specific pH range (approx. 8 to 9), but its IEP lies far from that of other proteins, no co-precipitate can form – thus, according to the AI definition (as the gold standard), the lactoferrin is both pure and native.
A special washing protocol is used to remove impurities, resulting in a pure, highly soluble powder following freeze-drying.
The process reduces costs (OPEX/CAPEX) by a good 50% and is 10 to 15 times faster, at significantly lower cost. The native product can be easily characterised by HPLC analysis, as high purity goes hand in hand with biological activity.

Electro-
Alkalinisation

Laboratory
1 -channel
System

Biological, infectious particles in air / aerosol

Bioway filed a patent to remove Sars-Cov-2 / Covid-19 and coming Coivid- Virus-Mutants out of the air / aerosol in real time by use of Infrared-Technology - which means a thermal inactivation. This application is designed for in-house use in closed rooms - but more for industrial application. It is substituting other technology like filter, UV-light, ionisation-, and plasma- application or air washer etc.The technology can also be used in air-conditioning systems, as is common in airports, large ships and bank and administrative buildings. The advantage is a long life time of years for IR-Elements because of air-cooling - only 144 Wh power-consumption and a small temperature difference of only 2.4°C to ambient. The thermal inactivation of any virus will happen without energy loss at the speed of light - without time delay. Even if the IR-elements are switched off, a reduction of 4% will happen - the system will stay free of microbial contamination.